Informações gerais

Detalhes sobre o exame

O Foundation One Heme concentra-se em cânceres hematológicos (leucemia, linfoma e mielona) e sarcomas. O exame detecta alterações genômicas em DNA de 405 genes relacionados ao câncer. Além disso, sequencia o RNA em 265 genes, para capturar ampla gama de fusões de genes. Auxilia na definição do plano terapêutico; Utiliza tecnologia NGS (sequenciamento de nova geração)

Prazo para resultado

20 dias corridos.

Genes analisados

Detecta alteração de base, indels e CNV em DNA de 405 genes relacionados ao câncer. Sequencia o RNA em 265 genes para capturar ampla gama de fusões de genes. Sequência inteira de codificação (substituições de base, indels e alterações do número de cópias): ABL1, ACTB, AKT1, AKT2, AKT3, ALK, AMER1 (FAM123B ou WTX), APC, APH1A, AR, ARAF, ARFRP1, ARHGAP26(GRAF), ARID1A, ARID2, ASMTL, ASXL1, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXL, B2M, BAP1, BARD1, BCL10, BCL11B, BCL2, BCL2L2, BCL6, BCL7A, BCOR, BCORL1, BIRC3, BLM, BRAF, BRCA1, BRCA2, BRD4, BRIP1 (BACH1), BRSK1, BTG2, BTK, BTLA, C11orf3O (EMSY), CAD, CALR, CARD11, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CCT6B, CD22, CD274 (PD-L1), CD36, CD58, CD70, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK 8, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHD2, CHEK1, CHEK2, CIC, CIITA, CKS1B, CPS1, CREBBP, CRKL, CRLF2, CSF1R, CSF3R, CTCF, CTNNA1, CTNNB1, CUX1, CXCR4, DAXX, DDR2, DDX3X, DNM2, DNMT3A, DOTIL, DTX1, DUSP2, DUSP9, EBF1, ECT2L, EED, EGFR, ELP2, EP300, EPHA3, EPHA5, EPHA7, EPHB1 ERBB2, ERBB3, ERBB4, ERG, ESR1, ETS1, ETV6, EXOSC6, EZH2, FAF1, FAM46C, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FAS (TNFRSF6), FBXO11, FBXO31, FBXW7, FGF10, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FHIT, FLCN, FLT1, FLT3, FLT4, FLYWCH1, FOXL2, FOXO1, FOXO3, FOXP1, FRS2, GADD45B, GATA1, GATA2, GATA3, GID4 (C17orf39), GNA11, GNA12, GNA13, GNAQ, GNAS, GPR124, GRIN2A, GSK3B, GTSE1, HDAC1, HDAC4, HDAC7, HGF, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H2AC, HIST1H2AG, HIST1H2AL, HIST1H2AM, HIST1H2BC, HIST1H2BJ, HIST1H2BK, HIST1H2BO, HIST1H3B, HNF1A, HRAS, HSP90AA1, ICK, ID3, IDH1, IDH2, IGF1R, IKBKE, IKZF1, IKZF2, IKZF3, IL7R, INHBA, INPP4B, INPP5D (SHIP), IRF1, IRF4, IRF8, IRS2, JAK1, JAK2, JAK3, JARID2, JUN, KAT6A (MYST3), KDM2B, KDM4C, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KIT, KLHL6, KMT2A (MLL), KMT2C (MLL3), KMT2D (MLL2), RAS, LEF1, LRP1B, LRRK2, MAF, MAFB, MAGED1, MALT1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAP2K4, MAP3K1, MAP3K14, MAP3K6, MAP3K7, MAPK1, MCL1, MDM2, MDM4, MED12, MEF2B, MEF2C, MEN1, MET, MIB1, MITF, MKI67, MLH1, MPL, MRE11A, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCL (MYCL1), MYCN, MYD88, MYO18A, NCOR2, NCSTN, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NOD1, NOTCH1, NOTCH2, NPM1, NRAS, NT5C2, NTRK1, NTRK2, NTRK3, NUP93, NUP98, P2RY8, PAG1, PAK3, PALB2, PASK, PAX5, PBRM1, PC, PCBP1, PCLO, PD GDI (PD-1), PDCD11, PDCD1LG2 (PD-L2), PD GFRA, PDGFRB, PDK1, PHF6, PIK3CA, PIK3CG, PIK3R1, P/IK3R2, PIM1, PLCG2, POT1, PPP2R1A, PRDM1, PRKAR1A, PRKDC, PRSS8, PTCH1, PTEN, PTPN11, PTPN2, PTPN6 (SHP-1), PTPRO, RAD21, RAD50, RAD51, RAF1, RARA, RASGEF1A, RBI, RELN, RET, RHOA, RICTOR, RNF43, ROS7, RPTOR, RUNX7, S1PR2, SDHA, SDHB, SDHC, SDHD, SERP2, SETBP1, SETD2, SF3B1, SGK1, SMAD2, SMAD4, SMARCA1, SMARCA4, SMARCB1, SMC1A, SMC3, SMO, SOCS1, SOCS2, SOCS3, SOX10, SOX2, SPEN, SPOP, SRC, SRSF2, STAG2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STK11, SUFU, SUZ72, TAF1, TBL1XR1, TCP3 (E2A), TCL1A (TCU), TET2, TGFBR2, TLL2, TMEM30A, TMSB4XP8 (TMSL3), TNFAIP3, TNFRSF11A, TNFRSF14, TNFRSF17, TOPI, TP53, TP63, TRAF2, TRAF3, TRAF5, TSC1, TSC2, TSHR, TUSC3, TTKZ, U2AF1, U2AF2, VHL, WDR90, WHSC1 (MMSET ou NSD2), WISP3, WT1, XBP1, XPO1, YY1AP1, ZMYMJ, ZNF217, ZNF24 (ZSCAN3), ZNF703, ZRSR2 - Rearranjos Selecionados do DNA3: ALK, BCL2, BCL6, BCR, BRAF, CCND1, CRLF2, EGFR, EPOR, ETV1, ETV4, ETV5, ETV6, EWSR1, FGFR2, IGH, G/C, IGL, JAK1, JAK2, KMT2A (MLL), MYC, NTRK1, PDGFRA, PDGFRB, RAF1, RARA, RET, ROS1, TMPRSS2, TRG - Fusões de genes de RNA Selecionados: ABl1, ABL1, ABL2, ACSL6, AFF1, AFF4, ALK, ARHGAP26 (GRAF), ARHGEF12, ARID1A, ARNT, ASX1L1, ATF1, ATG5 ATIC, BCL10 BCL11A, BCL11B, BCL2, BCL3, BCL6, BCL7A, BCL9, BCOR, BCR, BIRC3, BRAF, BTG1, CAMTA1, CARS, CBFA2T3, CBFB, CBL, CCND1, CCND2, CCND3, CD274 (PD-U), CDK6, CDX2, CHIC2, CHN1, CIC, CIITA, CLP1, CLTC, CLTCLI, CNTRL (CEP110), COL1A1, CREB3L1, CREB3L2, CREBBP, CRLF2, CSF1, CTNNB1, DDIT3, DDX10, DDX6, DEK, DUSP22, EGFR, EIF4A2, ELF4, ELL, ELN, EML4, EP300, EPOR, EPS15, ERBB2, ERG, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, FCGR2B, FCRL4, FEV, FGFR1, FGFRIOP, FGFR2, FGFR3, FLI1, FNBP1, FOXO1, FOXO3, FOXO4, FOXP1, FSTL3, FUS, GAS7, GLI1, GMPS, GPHN, HERPUD1, HEY1, HIP1, HIST1H4I, HLF, HMGA1, HMGA2, HOXA11, HOXA13, HOXA3, HOXA9, HOXC11, HOXC73, HOXD11, HOXD13, HSP90AA1, HSP90ABI, IGH, IGK, IGL, IKZF1, IL21R, IL3, IRF4, ITK, JAX7, JAK2, JAK3, JAZF1, KAT6A (MYST3), KDSR, KIF5B, KMT2A (MLL), LASP1, LCP1, LMOI, LMO2, LPP, LYL1, MAF, MAFB, MALT1, MDS2, MECOM, MKL1, MLF1, MLLT1 (END), MLLT10 (AF10), MLLT3, MLLT4 (AF6), MLLT6, MN1, MNX1, MSI2, MSN, MUC1, MYB, MYC, MYH11, MYH9, NACA, NBEAP1 (BCL8), NCOA2, NDRG1, NF1, NF2, NFKB2, NIN, NOTCH1, NPM1, NR4A3, NSD1, NTRK1, NTRK2, NTRK3, NUMA1, NUP214, NUP98, NUTM2A, OMD, P2RYB, PAFAH1B2, PAX3, PAX5, AAX7, PBX1, PCM1, PCSX7, PDCD1LG2 (PD-L2), PDE4DIP, PDGFB, PDGFRA, PDGFRB, PER1, PHF1, PICALM, PIM1, PLAG1, LMP, POU2AF1, PPP1CB, PRDM1, PRDM16, PRRXJ, PSIP1, PTCH1, PTK7, RABEP1, RAF1, RALGDS, RAP1GDS1, RARA, RBM15, RET, RHOH, RNF213, ROS1, RPL22, RPN1, RUNX1, RUNX1T1 (ETO), PLWXZ, SEC31A, SEPT5, SEPT6, SEPT9, SET, SH3GL1, SLC7A2, SNX29 (RUNDC2A), SRSF3, SS18, SSX1, SSX2, SSX4, STAT6, STL, SMC, TAF15, TALI, TAL2, TBL1XR1, TCF3 (E2A), TCL1A (TCL1), TEC, TET1, TFE3, TFG, TFPT, TFRC, TLX1, TLX3, TMPRSS2, TNFRSF11A, TOPI, TP63, TPM3, TPM4, TRIM24, TRIPP, TTL, TYK2, USP6, WHSC1 (MMSET ou NSD2), WHSC1L1, YPEL5, ZBTB16, ZMXMZ, ZNF384, ZNF521

Documentos necessários

Pedido Médico, Termo de consentimento, laudo de anatomia patológica